There’s a certain coziness that envelops a kitchen when I prepare my Cheesy Stuffed Meatloaf with Mozzarella. The tantalizing aroma of sizzling garlic dances through the air, teasing my family as they gather in anticipation. This dish is far more than just a meatloaf; it’s a delightful twist that transforms a classic into a hearty centerpiece bursting with flavor. Imagine slicing into that succulent loaf only to reveal a gooey, melty mozzarella center—it’s a surprise that never fails to bring smiles.

Whether it’s a chilly weeknight dinner or a special family gathering, this stuffed meatloaf shines as the ultimate comfort food. Plus, its flexible ingredients mean you can easily adjust to fit your pantry or preferences. Let’s dive into this recipe that’s sure to become a beloved staple in your home, impressing both cozy weeknight diners and picky eaters alike!

Why is Stuffed Meatloaf with Mozzarella a Must-Try?

Comfort at its finest: This stuffed meatloaf elevates a traditional dish to new heights, making it a go-to for family dinners.

Flavor explosion: The combination of savory beef and melty mozzarella offers a burst of deliciousness with each bite.

Flexible ingredients: Easily swap in what you have on hand—perfect for any kitchen and palate.

Impressive presentation: Slicing into a gooey mozzarella center is a showstopper that will have everyone raving!

Quick prep: With straightforward steps, you’ll have a hearty meal ready in no time, making busy weeknights more manageable.

Instant family favorite: Even picky eaters will be requesting this dish, turning mealtime into a cherished occasion.

Stuffed Meatloaf with Mozzarella Ingredients

• You’ll love how straightforward and flexible these ingredients are!

For the Meatloaf

Ground Beef (2 lbs) – Provides structure and heartiness; choose an 80/20 ratio for maximum juiciness.
Breadcrumbs (1/2 cup) – Binds the meatloaf together; substitute with crushed crackers or oats in a pinch.
Eggs (2 large) – Acts as a binder, essential for the meatloaf’s structure.
Milk (1/2 cup) – Adds moisture and richness; can be substituted with broth or a non-dairy alternative.
Onion (1 small) – Enhances flavor; finely chop for even distribution throughout the meatloaf.
Garlic (3 cloves, minced) – Provides aromatic depth; fresh garlic is best for flavor.
Worcestershire Sauce (2 tablespoons) – Adds savory complexity that deepens the overall flavor.
Tomato Paste (1 tablespoon) – Provides moisture and acidity, balancing the other flavors.
Salt (1 teaspoon) – Enhances overall flavor; don’t skip it for a tasty result!
Black Pepper (1/2 teaspoon) – Adds heat and a hint of spice to your meatloaf.
Dried Oregano (1 teaspoon) – Infuses an herby flavor that complements the meat perfectly.
Dried Basil (1 teaspoon) – Pairs beautifully with the mozzarella, enhancing Italian notes.
Shredded Mozzarella (1 1/2 cups) – The star of the dish, giving gooey goodness with each slice—pat fresh mozzarella dry for best results.

For the Glaze

Ketchup (1/3 cup) – Provides sweetness to balance the savory elements.
Brown Sugar (2 tablespoons) – Balances the acidity in the glaze for a well-rounded flavor.
Balsamic Vinegar (1 tablespoon) – Adds depth and richness to the glaze, elevating the entire dish.

Optional Garnish

Parsley (handful, optional) – For a touch of freshness and vibrant color on top of your stuffed meatloaf.

These ingredients come together to create a Stuffed Meatloaf with Mozzarella that’s not just ordinary, but truly extraordinary!

How to Make Stuffed Meatloaf with Mozzarella

Preheat the oven to 375°F. Start by preparing your baking sheet or loaf pan with nonstick spray to prevent any sticking, ensuring an easy release post-baking.
Combine the ingredients in a large bowl. Gently mix together the ground beef, breadcrumbs, eggs, milk, onion, garlic, Worcestershire sauce, tomato paste, salt, pepper, oregano, and basil by hand until just combined—don’t overmix, or your meatloaf may be tough!
Shape half of the beef mixture into a loaf base. You can do this on a clean surface or directly in the loaf pan. Be sure to create a trench down the center for the cheesy surprise.
Fill the trench with shredded mozzarella. Then, cover it up with the remaining meat mixture, making sure to seal the edges well so the gooey goodness stays inside while baking.
Prepare the glaze by mixing ketchup, brown sugar, and balsamic vinegar in a small bowl. Brush this mixture generously over the top of your meatloaf, adding a sweet and tangy finish.
Bake the meatloaf for 50-60 minutes. Check that the internal temperature reaches 160°F—if it starts browning too quickly, tent it with foil for the last few minutes to ensure even cooking.
Rest the meatloaf for 10 minutes after taking it out of the oven. This helps retain all that juiciness, making slicing easier and keeping flavors intact.

Optional: Garnish with chopped parsley for a fresh touch before serving.

Exact quantities are listed in the recipe card below.

What to Serve with Stuffed Meatloaf with Mozzarella?

Complement your dinner table with delightful sides that enhance the rich flavors of this savory meatloaf.

Creamy Mashed Potatoes: The smooth texture and buttery flavor create a comforting balance that perfectly complements the meatloaf’s heartiness.
Garlic Bread: This crispy, buttery delight adds a satisfying crunch and is great for scooping up any leftovers on your plate.
Roasted Green Beans: Their slight crunch and vibrant color bring a fresh contrast to the richness of the meatloaf, adding both nutrition and flavor.
Caesar Salad: The creamy dressing and crunchy croutons provide a crisp, refreshing side that cuts through the meatloaf’s richness beautifully.
Macaroni and Cheese: A gooey side that pairs well with stuffed meatloaf, offering a nostalgic comfort and cheese-on-cheese delight!
Balsamic Glazed Roasted Vegetables: These caramelized veggies not only add a pop of sweetness but also bring warmth and color to your meal, making it visually appealing.
Coleslaw: A tangy, crunchy salad that adds brightness and texture, balancing the heavy flavors of the meatloaf nicely.
Red Wine: A glass of medium-bodied red pairs exquisitely with the savory notes of the meatloaf, enhancing the overall dining experience.

Stuffed Meatloaf with Mozzarella Variations & Substitutions

Embrace the joy of experimenting with your stuffed meatloaf, allowing your creativity to flourish in the kitchen!

Ground Turkey: Swap ground beef for ground turkey for a lighter, leaner option. Dark meat turkey retains moistness beautifully!
Cheese Swap: Use cheddar, gouda, or even pepper jack for a new flavor twist on that melty center. Each cheese brings its own unique character.
Fresh Herbs: Substitute dried oregano and basil with fresh herbs for an aromatic uplift. A burst of bright flavors enriches each bite wonderfully.
Add Veggies: Incorporate finely chopped bell peppers or spinach into the meat mixture for extra nutrition and color. It’s a clever way to sneak in healthy greens!
Spicy Kick: Mix in red pepper flakes or diced jalapeños to add some heat and excitement to your meatloaf. Perfect for those who crave a little spice!
BBQ Twist: Use BBQ sauce instead of ketchup for the glaze to impart a smoky, tangy depth. This offers a delightful, bold flavor experience.
Oats for Breadcrumbs: Replace breadcrumbs with oats or crushed crackers if you’re aiming for a gluten-free version. The texture holds up beautifully!
Balsamic Glaze: Enhance the glaze with a tablespoon of honey for a sweeter finish that contrasts nicely with the savory meat. Your taste buds will thank you for the extra layer of flavor!

How to Store and Freeze Stuffed Meatloaf with Mozzarella

Fridge: Store leftover stuffed meatloaf in an airtight container for up to 3 days. Reheat in the oven at 350°F for best texture.

Freezer: Wrap the meatloaf tightly in plastic wrap and then in aluminum foil. It can be frozen for up to 3 months without losing flavor.

Make-Ahead: Prepare the meatloaf mixture a day in advance and store it uncooked in the fridge. Bake when you’re ready for a cozy dinner.

Reheating: For optimal results, reheat slices in the oven until warmed through, ensuring the cheesy center remains gooey and delicious.

Make Ahead Options

These Stuffed Meatloaf with Mozzarella are perfect for busy home cooks looking to save time! You can prepare the meatloaf mixture and form it into a loaf up to 24 hours in advance; just cover it tightly with plastic wrap and refrigerate. The mozzarella center can be filled ahead of time for extra convenience. When you’re ready to serve, simply pop it in the oven and bake as instructed. To maintain quality, make sure to seal the edges well to prevent the cheese from leaking and keep it juicy. Allow it to rest for 10 minutes after baking, and you’ll enjoy deliciously satisfying results with minimal fuss!

Expert Tips for Stuffed Meatloaf with Mozzarella

Seal the Edges: Ensure you seal the edges well after filling the trench with mozzarella; this keeps the cheese contained during baking.
Resting Time: Allow your meatloaf to rest for about 10 minutes after baking. This lets the juices redistribute, preventing dryness when you slice it.
Choosing Meat: If using ground turkey, opt for dark meat for better moisture and flavor. Leaner meats can result in a drier meatloaf.
Breadcrumb Adjustments: If your meatloaf falls apart when slicing, add a bit more breadcrumbs during mixing for better binding.
Ingredient Flexibility: Feel free to experiment with fresh herbs instead of dried for an herby freshness that elevates the flavor of your Stuffed Meatloaf with Mozzarella.

Stuffed Meatloaf with Mozzarella Recipe FAQs

What kind of ground beef should I use for the meatloaf?
Absolutely! For the best flavor and juiciness, I recommend using an 80/20 ground beef ratio. This means 80% lean meat and 20% fat, which ensures your meatloaf remains juicy and flavorful. If you’re looking for a lighter option, ground turkey can work beautifully—just opt for dark meat to maintain moisture.

How do I store leftover stuffed meatloaf?
Very simple! After allowing your meatloaf to cool, store it in an airtight container in the fridge for up to 3 days. Reheating it in the oven at 350°F will help retain its texture. This way, you’ll savor the flavors all over again!

Can I freeze stuffed meatloaf?
Absolutely! To freeze your stuffed meatloaf, wrap it tightly in plastic wrap, then in aluminum foil to prevent freezer burn. It can be stored in the freezer for up to 3 months. When you’re ready to enjoy it, just thaw it in the fridge overnight before reheating.

What should I do if my meatloaf falls apart when slicing?
Very common! If your meatloaf crumbles when you slice it, you might need to adjust your binding agents. I suggest adding an extra tablespoon or two of breadcrumbs to help hold it together. Make sure to combine everything gently and let it rest for about 10 minutes before slicing to allow the juices to redistribute.

Are there any allergens in the recipe I should be aware of?
Great question! The primary allergens in this stuffed meatloaf are eggs and dairy from the mozzarella. If you’re cooking for someone with allergies, consider using a non-dairy cheese and a flaxseed or chia egg as a substitute for binding. Always check your ingredient labels for hidden allergens!